The article is called “Analysis of the immune system of multiple myeloma patients achieving long-term disease control by multidimensional flow cytometry.” It makes me think they mean long-term disease control was achieved by flow cytometry. That would be pretty awesome. They really mean that the analysis was done using MFC.
Multiple myeloma remains largely incurable. However, a few patients experience more than 10 years of relapse-free survival and can be considered as operationally cured. Interestingly, long-term disease control in multiple myeloma is not restricted to patients with a complete response, since some patients revert to having a profile of monoclonal gammopathy of undetermined significance.
My comments: How can the monoclonal gammopathy be characterized as being of undetermined significance, when the pt has had MM? Obviously, there is a significance. I’m just picking. I know what they mean. It’s good to see that they’re asserting that complete response is not required. I have never had that. I think people put too much emphasis on it.
In summary, our results indicate that multiple myeloma patients with long-term disease control have a constellation of unique immune changes favoring both immune cytotoxicity and recovery of B-cell production and homing, suggesting improved immune surveillance.
My Comments: None, really. I just like the word constellation. :) Dr. Peterson used to use that word a lot.
Despite the fact that until recently MM was considered incurable, the introduction of high dose therapy/autologous stem cell transplantation and novel drugs has made it possible for a small fraction of patients to attain long-term (≥5 years) disease control even in the absence of a complete response, after reverting to having an MGUS-like profile. The underlying mechanisms leading to disease suppression in these patients are largely unknown, although immune surveillance has been hypothesized to play a critical role.
My Comments: This is me, in a nutshell. The small fraction.
Six years ago on this date, I had a stem cell transplant at Duke Medical Center.
You can read what I wrote that day by clicking on the picture of my stem cells. I didn’t document it very well. I remember feeling just terrible when the stem cells were being injected into my line. I felt so bad that they gave me something that pretty much knocked me out. It felt like someone punched me in the chest. I felt sick, too. I can’t even remember if I took this picture, or if someone else did. Ativan. :)
This is the latest report I have. I had blood drawn at the beginning of June. You can click on the small image of the report to see it full size.
It indicates that I’m still stable. From quarter to quarter, there are small changes, but nothing significant. Sometimes the values go up and sometimes down. There’s nothing exciting to report this time.
I’m still taking 8 grams of curcumin each day, along with cinnamon, coconut oil, flax oil and krill oil.
I see the oncologist every three months, and have Zometa every three months, too. My bone density is normal.
There’s really not much to talk about, where the myeloma is concerned. It continues to lurk, without doing anything (that I’m aware of). It behaves like SMM.
I’ve not had any maintenance therapy since the SCT, which took place at the end of August in 2007.
It’s been a while since this was written, but I just became aware of this NPR story about Minnesota Don. Don’s an amazing person, in every way.
Targeted Cancer Drugs Keep Myeloma Patients Up And Running
Don Wright got diagnosed with multiple myeloma at what turned out to be the right time. It was 10 years ago, when he was 62.
That was at the beginning of a revolution in treating this once-fearsome , which strikes around every year. The malignancy can literally eat holes in victims’ bones, which can snap from the simple act of bending over to pick up a package.
I have never met Don in person, but I have spoken to him on the phone, and he even did me a super big favor once. A couple of times. He’s been great about sharing his experiences with the myeloma treatments he’s undergone. He’s been on pomalyst lately, which is a new-ish drug for mm patients.
Hey! Run, do not walk, over to Margaret’s blog now and read about the work of Jay Bradner, who just may have figured out a way to stop myeloma dead in its tracks. After watching the video below, I started wishing I was a mouse!
Please read it and let me know what you think. I’ve long thought I probably should have held off on treatment for as long as possible, and my post-SCT strategy is to stay treatment free for as long as possible. I expect to withhold treatment until symptoms affect QOL.