This is my neighborhood. How weird that nearly 1000 people have watched it.
I had last week off treatment, which was nice. This week I just had Zometa, which I learned from others never to have on the same day as Velcade. They reported severe flu-like symptoms, which I want to avoid! I had blood drawn today, and can call on Thursday or Friday to find out what my m-spike and IgA are. We’re expecting it to be lower than last time. I haven’t had the standard 21 day cycles of Velcade and Doxil. My doctor is doing it in 28 day cycles. I don’t mind. I only hope it’s as effective. The hives I got after the last injection are still here, so I’m going to take Eric’s advice and have IV benedryl and decadron next time. That’ll be Tuesday.
This is my dog, Buddy, at the park yesterday. He loves this more than anything in the world! Click on play to watch the video.
Yesterday when I woke up I had what looked like a couple dozen mosquito bites on my torso. They don’t hurt or itch. They’re just there. The same today, too. I think there might be a few more. I didn’t count them yesterday, so I don’t know for sure. I guessed that they might be from chemo. I finished a round of Velcade + Doxil Friday. Since they don’t hurt or itch, are visible to the public or bother me in any way, I’ll see if they’re still there tomorrow. If they are, I’ll call the doctor. I don’t think they’re anything to be alarmed about.
Here’s some advice I got about Velcade/Doxil from one of the researchers involved in early trials. I thought I’d pass it on.
With the Velcade and Doxil, have they started you on oral Vit B6? When we used to run the Phase I study of that combination, we have recommended pyridoxine (Vit B6) 200 mg by mouth daily. I think this is even over the counter but you can definitely let your local doctor be aware that you are taking this. This drug is to prevent the hand-foot syndrome which is a potential side-effect of the Doxil.
There is also the risk of neuropathy with Velcade. A patient once told me that the Velcade neuropathy (which is more of pain) is different than the Thalidomide/Revlimid neuropathy (which is more of the numbness and tingling sensation). As of this time, there is no approved treatment for neuropathy or formal studies comparing all the drugs that are being used to alleviate neuropathy. We have been using either Neurontin or Lidocaine patch.
Here are the before and after lab results. They’re from different labs, so they’re like comparing green apples to red apples, but there’s enough of a difference to indicate that Velcade + Doxil is working for me. Next time, the blood will be sent to Horizon.
Total protein: 8.3 g/dL (ref range: 6.0-8.3 g/dL)
M-spike 1: 1.2 g/dL
M-spike 2: 0.4 g/dL
IgA: 2116 mg/dL (ref range: 81-463 mg/dL)
Total protein: 7.6 g/dL (ref range: 6.0-8.3 g/dL)
M-spike 1: 0.75 g/dL
M-spike 2: 0.32 g/dL
IgA: 1350 mg/dL (ref range: 68-378 g/dL)
IgG: 354 mg/dL (ref range: 694-1618 g/dL)
IgM: 21 mg/dL (ref range: 60-263 mg/dL)
HealthBlogs is open for business now. It provides free blogs, just like this one, to anyone who is facing a health challenge, caregivers, healthcare professionals and people who are interested in health and fitness. Please stop by www.healthblogs.org to create a blog for yourself, and please tell a friend (or 10)!
I’ve been blogging for about 4 years now, and Ive found that it not only helps me. I’ve received email and comments from hundreds of people who are facing similar struggles or know someone who is.