Month: February 2009

RSS Feed aggregator for myeloma blogs

I’m putting my links to blogs into a feed aggregator. If your blog has an RSS feed and you’d like to have it on the list, let me know. Just us the contact form.Ā  Don’t forget to tell me what the URL for your valid RSS feed is.

http://www.myelomablogs.org/?type=archive

If you don’t have a blog or an RSS feed, why not set up one at healthblogs.org?

Find out what others are doing: myeloma treatment, chemo, coping

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors

This caught my eye because I’ve been on Velcade before and never gave a second thought to whether or not I should not be consuming green tea/green tea products.

Blood First Edition Paper, prepublished online February 3, 2009; DOI 10.1182/blood-2008-07-171389.

Submitted July 28, 2008
Accepted January 12, 2009

Encouse B. Golden, Philip Y. Lam, Adel Kardosh, Kevin J. Gaffney, Enrique Cadenas, Stan G. Louie, Nicos A. Petasis, Thomas C. Chen, and Axel H. Schonthal*

Department of Pathology, University of Southern California (USC) Keck School of Medicine (KSOM), Los Angeles, CA, United States
Department of Molecular Pharmacology and Toxicology, USC School of Pharmacy (SoP), Los Angeles, CA, United States
Department of Molecular Microbiology and Immunology, USC KSOM, Los Angeles, CA, United States
Department of Chemistry, USC College of Letters, Arts and Sciences, Los Angeles, CA, United States
Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, USC SoP, Los Angeles, CA, United States
Department of Neurosurgery, USC KSOM, Los Angeles, CA, United States

* Corresponding author; email: schontha@usc.edu.

The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this ‘miracle herb’ in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (VelcadeĀ®) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the combination of these compounds would yield increased antitumor efficacy in multiple myeloma and glioblastoma cell lines in vitro and in vivo. Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by bortezomib in vitro and in vivo. This pronounced antagonistic function of EGCG was only evident with boronic acid-based proteasome inhibitors (bortezomib, MG-262, PS-IX), but not with several non-boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir). EGCG directly reacted with bortezomib and blocked its proteasome inhibitory function; as a consequence, bortezomib could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death. Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib and suggest that consumption of green tea products may be contraindicated during cancer therapy with bortezomib.

Exactly how to throw a party

What a great party! We had the honor of attending our sister’s 50th birthday party last night. It was perfect! The guests were a great group of people, the food was outstanding and the music was great. This one surpassed even a “Night Affair on Elm Street.”

Everyone should now go on over to the WriterHouse web site to make a donation in honor of Rachel’s birthday.

Beautifully presented food was a part of the celebration
Beautifully presented food was a part of the celebration