Author: Beth

I was diagnosed with MM in January of 2003. I underwent various treatments, including thalidomide/dex, revlimid/dex, dex alone, a clinical trial of CNTO 328, and Velcade, Doxil and dex until late August, 2007, when I had an autologous stem cell transplant after high dose melphalan. I experienced what's known as a very good partial response (VGPR). Since then, my myeloma has been stable.

Flashing lights

Southern Pines Police car flashing lights This evening was the second of eight sessions of this year’s Southern Pines Police Citizens Police Academy. If your community’s police department has a program like this, I encourage you to get involved. It doesn’t seem like eight weeks is enough time to learn all there is to know.

During the first session, we had an introduction to the department and its functions given by Chief John Letteney, Community Services Coordinator, Bob Temme and the department’s chaplain.

Today’s lecture and demonstrations were conducted by Sgt Austin, who described the functions and responsibilities of the patrol division. We got to tour the department offices and take a look at some of the equipment used in patrol cars.

We talked a lot about impaired drivers and the methods used to determine the level of impairment by officers on patrol. Can you believe that there are people who think they can alter the results of breath alcohol detection instruments by putting a penny in their mouths?  Weird, I know.  I said I think we should start a rumor that putting a cat turd in your mouth will cause a negative reading.  I’d love to imagine drunk drivers sucking on cat turds when they get pulled over.  We laugh when we hear the stories about how impaired drivers bumble through field sobriety tests, but there’s really nothing funny about it. Drunk drivers are potential killers who have no care for the safety and well-being of others. I barely remember him, but my uncle was killed by a drunk driver.

Next week I’ll have some more pictures!

Tadpole Salad

This is a video of some tadpoles that live in the water that’s collected on top of my pool cover. They’re eating some salad greens I tossed onto the water for them. There are hundreds left, even though I’ve given at least a hundred away for kids to watch as they develop into toads or frogs, or whatever they’ll be. They don’t have legs yet, so it could be some weeks before they leave. If you’re local and would like some pollywogs for your classroom aquarium, let me know.

This and that

One of my classmates from the Travel Channel Academy has used her video skills to win the use of a car!

“I am one of 100 people to win a 2011 Ford Fiesta (international model) for 6 months! Be sure to check my blog (http://hotfuzzonmylegs.blogspot.com) and twitter (www.twitter.com/lex112884) for more info and to learn more about the winnings!”

That’s very cool.  I haven’t done much video myself, but have some projects in the works.  Just local stuff, which I’ll post when it’s ready.

I’ve been approved to attend the tenth session of the Southern Pines Police Department’s Citizen’s Police Academy, and am looking forward to participating. My nephew wonders if that means Buddy will get to be a police dog.

I have Zometa tomorrow.  It’s been a while since I did that, but there’s a possibility (I’m told) that it has an anti-myeloma effect. I only have it about 3-4 times a year now.

RSS Feed aggregator for myeloma blogs

I’m putting my links to blogs into a feed aggregator. If your blog has an RSS feed and you’d like to have it on the list, let me know. Just us the contact form.  Don’t forget to tell me what the URL for your valid RSS feed is.

http://www.myelomablogs.org/?type=archive

If you don’t have a blog or an RSS feed, why not set up one at healthblogs.org?

Find out what others are doing: myeloma treatment, chemo, coping

Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors

This caught my eye because I’ve been on Velcade before and never gave a second thought to whether or not I should not be consuming green tea/green tea products.

Blood First Edition Paper, prepublished online February 3, 2009; DOI 10.1182/blood-2008-07-171389.

Submitted July 28, 2008
Accepted January 12, 2009

Encouse B. Golden, Philip Y. Lam, Adel Kardosh, Kevin J. Gaffney, Enrique Cadenas, Stan G. Louie, Nicos A. Petasis, Thomas C. Chen, and Axel H. Schonthal*

Department of Pathology, University of Southern California (USC) Keck School of Medicine (KSOM), Los Angeles, CA, United States
Department of Molecular Pharmacology and Toxicology, USC School of Pharmacy (SoP), Los Angeles, CA, United States
Department of Molecular Microbiology and Immunology, USC KSOM, Los Angeles, CA, United States
Department of Chemistry, USC College of Letters, Arts and Sciences, Los Angeles, CA, United States
Department of Clinical Pharmacy and Pharmaceutical Economics and Policy, USC SoP, Los Angeles, CA, United States
Department of Neurosurgery, USC KSOM, Los Angeles, CA, United States

* Corresponding author; email: schontha@usc.edu.

The anticancer potency of green tea and its individual components is being intensely investigated, and some cancer patients already self-medicate with this ‘miracle herb’ in hopes of augmenting the anticancer outcome of their chemotherapy. Bortezomib (Velcade®) is a proteasome inhibitor in clinical use for multiple myeloma. Here, we investigated whether the combination of these compounds would yield increased antitumor efficacy in multiple myeloma and glioblastoma cell lines in vitro and in vivo. Unexpectedly, we discovered that various green tea constituents, in particular (-)-epigallocatechin gallate (EGCG) and other polyphenols with 1,2-benzenediol moieties, effectively prevented tumor cell death induced by bortezomib in vitro and in vivo. This pronounced antagonistic function of EGCG was only evident with boronic acid-based proteasome inhibitors (bortezomib, MG-262, PS-IX), but not with several non-boronic acid proteasome inhibitors (MG-132, PS-I, nelfinavir). EGCG directly reacted with bortezomib and blocked its proteasome inhibitory function; as a consequence, bortezomib could not trigger endoplasmic reticulum stress or caspase-7 activation, and did not induce tumor cell death. Taken together, our results indicate that green tea polyphenols may have the potential to negate the therapeutic efficacy of bortezomib and suggest that consumption of green tea products may be contraindicated during cancer therapy with bortezomib.

Exactly how to throw a party

What a great party! We had the honor of attending our sister’s 50th birthday party last night. It was perfect! The guests were a great group of people, the food was outstanding and the music was great. This one surpassed even a “Night Affair on Elm Street.”

Everyone should now go on over to the WriterHouse web site to make a donation in honor of Rachel’s birthday.

Beautifully presented food was a part of the celebration
Beautifully presented food was a part of the celebration