Back to getting talquetamab every week

I was getting talquetamab every other week for what seemed like a short while.  I think it might have been two cycles. The talq dose was triple the dose I had been receiving every week.  I had pretty severe headaches on the increased dose.  I tried to hang in there, but it was bad enough that the only thing that would help was oxycodone.  I was wasting a lot of time feeling really miserable, and was considering quitting the trial.

Now that I’m back on weekly talq, I feel better.

These are the side effects I continue to have.  I am in cycle 12 now.

  • Altered sense of taste.  Most things are tasteless or flavor is significantly reduced.
  • Difficulty swallowing.
  • Dry mouth.
  • Sore scalp.
  • Weird kind of electrical zappy, prickly feeling when I get too hot.  It doesn’t seem as bad as it once was, but I will see how it goes as the outdoor temperature increases.
  • Chills and fever 4-5 days after injection. I use Advil to treat and report it to the on-call oncologist, no matter what time of day or night.
  • Headache that starts 3 days after injection. No longer severe. It can be treated with OTC Excedrin or similar. It usually only lasts one day.
  • Fatigue.  This could also be due to other drugs.
  • Nail issues. My nails chip and tear. They also are very sensitive, making it a little bit difficult to type. I can’t do things like open cat food cans or drink cans with my nails anymore. They no longer look like this, thank goodness.

I am also on daratumumab once per cycle.  I take 40 mg of dex each week. I am on a 21 day cycle of Pomalyst.  I have Zometa every 3 months.

Do you all have to take an antibiotic and antiviral prophylactically?

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