My feet are pretty much numb up to my ankles from thalidomide. I feel (or don’t feel it?) it most in my toes and the soles of my feet. I was on the supplements suggested to me by Dr. Richardson at Dana-Farber for the entire time I was on thal, and continued it beyond stopping thal. It didn’t do much for me. I had acupuncture the entire time I was on thal, and that didn’t help either. Does anyone know of anything that does help? Is the damage permanent? I’m very glad I stopped thal when I did. I wish I had stopped sooner! I do want to add that the PN did progress after I stopped. It did get worse.