I have the distinct feeling that CNTO 328 isn’t helping me. My IgA was in the 1800s before I quit dex, but then dropped to the 1600s during my “wash out” period before I began the CNTO trial. During the trial, my serum IgA has been in the 2000-2400 mg/dL range. At the last test, it was 2300.
I’m interested in enrolling in the Multicenter, Open-Label, Single-Arm, Expanded Access Program For Lenalidomide Plus Dexamethasone In Previously Treated Subjects With Multiple Myeloma. There are two in North Carolina. One is at Winston-Salem and one is in Charlotte. Charlotte is a miserable two hour drive. W-S is about 110 miles from here, but good roads with a higher speed limit. I have emailed the Principal Investigator, and so has my doctor. They are currently not recruiting, but the study may be opened up in about 4 weeks. The Charlotte place IS recruiting. I’m going to try to hold out. I’m sure I’ll survive another 4-6 weeks. There’s a 28 day wash out period, so it would be nice to know if I should stop the CNTO now.
My BMB showed no change in the per centage of plasma cells between the start and official end of the CNTO trial, so they considered that a stable disease. My IgA has gone up 700 mg/dL though. Did you know that, to be called disease progression, the MM has to advance by 25%?